Angry Robot has opened to submissions from author without agents. Here’s the link.

And this is what they are looking for:

We’re publishing novels, either standalone or as part of greater series. We’re not looking to publish your novellas, short stories or non-fiction at this time.

All our books are “genre” fiction in one way or another — specifically fantasy, science fiction, horror, and that new catch-all urban or modern fantasy. Those are quite wide-ranging in themselves; we’re looking for all types of sub-genre, so for example, hard SF, space opera, cyberpunk, military SF, alternate future history, future crime, time travel, and more. We have no problem if your book mashes together two or more of these genres; in fact, we practically insist upon it.

Our books will be published in all English-language territories — notably the UK, US and Australia — so we’ll be buying rights to cover all those. If you are only offering rights in one territory, we will not be able to deal with you. We will be able to offer e-book and audio versions as standard too, plus limited edition and multiple physical formats where appropriate. We are not contracting any work-for-hire titles; we offer advances and royalties.

Beyond all of this, what we’re really looking for in your writing is this:
• A “voice”, that comes from…
• Confident writing
• Pacy writing
• Characters that live, have real relationships and emotions, even in extreme situations
• A sense of vision, a rounded universe that lives and breathes
• Clever construction, good plotting, a couple of surprises even for us jaded old read-it-alls
• Heightened experience – an intensity, extremity or just a way of treating plot or situation in a way we’ve not come across before. “Goes up to 11″, if you know what that means.

Do all those, and it will be almost irrelevant that your story is one or other sub-set of SF, fantasy or horror!